Enterococcus faecalis produces extracellular superoxide and hydrogen peroxide that damages colonic epithelial cell DNA
نویسندگان
چکیده
منابع مشابه
Contribution of catalase to hydrogen peroxide resistance in Enterococcus faecalis.
Enterococcus faecalis exhibits high resistance to oxidative stress. Several enzymes are responsible for this trait. The role of alkyl hydroperoxide reductase (Ahp), thiol peroxidase (Tpx), and NADH peroxidase (Npr) in oxidative stress defense was recently characterized. Enterococcus faecalis, in contrast to many other streptococci, contains a catalase (KatA), but this enzyme can only be formed ...
متن کاملEnterococcus faecalis Produces Abundant Extracellular Structures Containing DNA in the Absence of Cell Lysis during Early Biofilm Formation
UNLABELLED Enterococcus faecalis is a common Gram-positive commensal bacterium of the metazoan gastrointestinal tract capable of biofilm formation and an opportunistic pathogen of increasing clinical concern. Dogma has held that biofilms are slow-growing structures, often taking days to form mature microcolonies. Here we report that extracellular DNA (eDNA) is an integral structural component o...
متن کاملInhibition of Enterococcus faecalis by Calcium Peroxide.
OBJECTIVE To investigate the inhibition of Enterococcus faecalis by calcium peroxide (CaO₂). METHODS The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Enterococcus faecalis by CaO₂ and calcium hydroxide (Ca(OH)₂) were determined by direct exposure tests (n = 10). The inhibition zone of E. faecalis mycoderm treated with CaO₂ and Ca(OH)₂ paste (53% w/w) ...
متن کاملHydrogen peroxide induce modifications of human extracellular superoxide dismutase that results in enzyme inhibition☆
Superoxide dismutase (EC-SOD) controls the level of superoxide in the extracellular space by catalyzing the dismutation of superoxide into hydrogen peroxide and molecular oxygen. In addition, the enzyme reacts with hydrogen peroxide in a peroxidase reaction which is known to disrupt enzymatic activity. Here, we show that the peroxidase reaction supports a site-specific bond cleavage. Analyses b...
متن کاملSynergistic antibacterial activity of chlorhexidine and hydrogen peroxide against Enterococcus faecalis.
The aim of the present study was to compare the in vitro antibacterial activity of common root canal irrigants with a combination technique against intratubular Enterococcus faecalis. Seventy-five human single-rooted teeth were selected and their crowns and root-ends were removed to obtain specimens 5 mm in length. The specimens were contaminated with E. faecalis and divided into five experimen...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2002
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/23.3.529